Pfizer Inc., one of the trifecta pharmaceutical companies manufacturing COVID-19 vaccines, is acquiring another large pharma company that is conduction clinical trials on a variety of drugs, including one that is examining the efficacy of cannabinoids.
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Pfizer Inc. announced the planned acquisition of Arena Pharmaceuticals, Inc. on December 13. The two companies signed an agreement stating that Pfizer would receive all shares of Arena for $100 per share, paid in cash at the value of the agreement set to $6.7 billion. Arena offers a variety of multi-stage clinical trials for the drugs they’re currently developing—one of which is exploring the use of an oral cannabinoid medicine for gastrointestinal disorders.
According to a press release, the board of directors for both Pfizer and Arena approved of the deal. “The proposed acquisition of Arena complements our capabilities and expertise in Inflammation and Immunology, a Pfizer innovation engine developing potential therapies for patients with debilitating immuno-inflammatory diseases with a need for more effective treatment options,” said Pfizer Global President & General Manager Mike Gladstone. “Utilizing Pfizer’s leading research and global development capabilities, we plan to accelerate the clinical development of etrasimod for patients with immuno-inflammatory diseases.” Gladstone operates under the Pfizer inflammation and immunology department.
Arena has been working on a multitude of “development stage therapeutic candidates,” ranging from gastroenterology, dermatology, cardiology and more. One particular treatment of note is etrasimod, which is being tested as a treatment for ulcerative colitis and Crohn’s disease. Other drug candidates for gastroenterology, dermatology and cardiology.
Furthermore, Arena has been working on an antagonist for a cannabinoid type 2 receptor. According to an interview with Nawan Butt, a portfolio manager of The Medical Cannabis and Wellness ICITS ETC, he mentions the importance of this deal to further push progress for medical cannabis research opportunities. “This acquisition displays the interest big pharma is taking in the fast-evolving world of cannabinoids. We are encouraged by the acquisition as it provides more resources and a wider platform for pharmaceutical development of cannabinoids. Overall, this transaction is in line [with] Pfizer’s long-term focus on innovative research and a great win for our investors,” he told proactiveinvestors.com.
Arena’s involvement in cannabinoid research is related to its drug candidate, Olorinab (APD371). “Olorinab (APD371) is an investigational, oral, peripherally acting, highly selective, full agonist of the cannabinoid type 2 receptor (CB2). Olorinab is an internally discovered drug candidate that Arena is exploring for development in several indications, with an initial focus on visceral pain associated with gastrointestinal disorders,” Arena’s website reads. “This compound, through its selectivity for CB2 versus CB1, is under investigation for pain relief without psychoactive adverse effects.”
Aside from official clinical trials, cannabis research has been growing rapidly over the past decade. But in early November, NORML released a compilation of 450 peer-reviewed studies in “Clinical Applications for Cannabis & Cannabinoids: A Review of the Recent Scientific Literature, 2000-2021.”
The compilation showcases the wide variety of studies examining cannabis in conjunction with autism, chronic pain, diabetes, fibromyalgia, migraines and PTSD. Studies such as these are likely to become the building blocks for clinical trials down the line. “NORML has long advocated for the enactment of evidence-based marijuana policies,” said the review’s main author, NORML Deputy Director Paul Armentano. “When it comes to addressing questions specific to the safety and therapeutic efficacy of cannabis, this publication provides the evidence that patients and their physicians—as well as lawmakers—need to know.”
From studies on cannabis as an aid for sleep to exercise, the researchers in the U.S. are poised to continue conducting studies on cannabis for years to come, paving the way for more clinical trials to be conducted as well.
Delta-8 is legal federally, and most state laws don't specifically address it. Due to ambiguities in the 2018 farm bill, which legalized hemp and hemp products, delta-8 is currently not prohibited by federal law.
In the human body, Delta-8 binds to the CB1 and CB2 receptors. Because it binds to both receptors simultaneously, users experience a milder cerebral high. When compared to the effects of THC, users describe a more clear-headed, productive, energetic, and upbeat feeling.
Difference Between Delta-8 THC and CBD Delta-8 THC may not be as prominent as Delta-9 THC, but it is still among the predominant cannabinoids with psychoactive properties. However, CBD is NOT a psychotropic cannabinoid. While CBD can have better results in the long run, Delta-8 THC can give you a quick fix.
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Delta-8 is considered a Schedule 1 Controlled Substance by the US Drug Enforcement Administration (DEA) because it is known to cause psychoactive impairment to the consumer.
Delta-9 THC is a property of cannabis discovered all the way back in 1964. The primary difference between Delta-8 THC and Delta-9 THC is that Delta-8 is just a bit less psychoactive than Delta-9. This means that products with Delta-8 THC have a more gradual, and therefore more satisfying, effect on the consumer.
Although in an edible form, Delta-8 THC can metabolize into a natural chemical called 11 Hydroxy tetrahydrocannabinol. Since 11 Hydroxy THC can only be absorbed through the liver, the molecule's possible psychoactive effects can last up to 6 to 8 hours during digestion.
According to the NCI, Delta-8 uniquely binds twice with cannabinoid receptors in the nervous system that play a role in sleep by calming down processes like breath, heart rate, and mental activity.
Delta-8 THC is one of the hottest topics in cannabis right now. It's a minor cannabinoid that can get you high like traditional THC, but much less so. Delta-8 found in small amounts in the cannabis plant and is often converted from other compounds like CBD.
5 benefits delta 8 could offer you According to the National Cancer Institute, delta-8 THC can bind to the CB1 receptor throughout the body. These receptors are part of our endocannabinoid system, which helps our body regulate and maintain homeostasis.
Delta-8 is yet another compound derived from Cannabis sativa or the hemp plant. As you likely know by now, this is the same natural origin that CBD, THC, CBG, CBN, and CBC come from, too. Though all of these compounds are related to some degree, delta-8 is closest to CBD and delta-9 (also often known plainly as THC).
Delta-8 may not produce intense euphoria, but it will take effect pretty quickly. Depending on your mode of intake, of course, the time of impact will vary. If you vape it, you will experience the effects within 1 to 6 minutes. If you use a tincture, you will get the first effects after half an hour.
The Short Answer: Yes. Hemp-derived Delta-8 THC products, containing less than 0.3% D-9 THC is legal in all 50 states of the USA. But what if the extract contains more than 0.3% Delta-9 THC?
A research study from 2004 concluded that delta-8 helps increase appetite while promoting weight loss. This effect is certainly very unique, and scientists will do even more research on this subject. These effects might be due to the potential benefits delta-8 has on metabolism.
Yes, Delta 8 can make you feel hungry. Delta 8 is an appetite-stimulating analogue of tetrahydrocannabinol (or THC). Of course this depends on the amount you smoke (vapes) or consume (edibles), but Delta 8 has been reported to stimulate your appetite, in some cases, even more than Delta 9 (marijuana).
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Delta-8 THC actually converts into delta-11 THC when processed through the digestive tract. Since delta-9 THC also converts into delta-11 THC when eaten, there's no special benefit to eating delta-8 THC. In general, research suggests that delta-8 has about two-thirds of the potency of delta-9.
In the present study, we have demonstrated that Δ8-THCV exerted protective effects against liver I/R reperfusion damage by attenuating tissue injury, oxidative stress and inflammatory response.
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