Reporters often file the smuggling of sassafras trees out of Southeast Asian jungles; lumber hasactually been seen periodically loaded out in the back of household sedans. One factor consistsof MDMA production which partly depends on safrole oil. But the trees utilized to produce the chemical are not sustainable. Saving a forest is one factor to establish a brand-new technique for the sustainable massive production of cGMP certified MDMA.

Before cGMP and Shulgin, there was Merk

3,4-Methylenedioxymethamphetamine (MDMA) was patented by Merk in1912 The pharmaceutical huge was the veryfirst to test the substance, togetherwith the US Army. Coincidentally, MDMA was rebirthed by chemists in the 1960s utilizing the exactsame production approach as Merk.

The veryfirst synthesis of MDMA utilized safrole oil as a beginning representative, transformed with methylamine. Piperonal was ultimately utilized as a beginning representative as well, lowered with iron in hydrochloric acid. Alexander Shulgin used the latter synthesis in1986 And while MDMA can be made from other beginning products. No recorded procedure has complied with pharmaceutical requirements upuntil the release of a researchstudy task moneyed by MAPS. (1)

Shulgin was a proficient chemist, but the law forbade his syntheses from any cGMP or FDA compliant process.
The late Dr. Alexander Sasha Shulgin in his private laboratory.

cGMP MDMA, an market veryfirst

Phase 3 medical trials successfully cleaned MDMA from Schedule 1 of the Controlled Substances Act by proving its medical practicality. Clinical results drew the requirement for therapeutically practical MDMA for clients dealingwith PTSD, social stressandanxiety from Autism Spectrum condition, and even alcoholaddiction.

While the Food and Drug Agency manages regulated Good Manufacturing (cGMP) Policies. The FDA was established just 6 years after Merk developed its early MDMA patent. cGMP accreditation suggests that the whole production procedure, not simply the last item, follows a set procedure.

Modern MDMA synthesis

The cGMP synthesis begins with a particle including a derivative of a six-membered carbon ring discovered in nature, however not obtained from safrole oil or piperine. Further opposing the usage of sassafras, other reagents likewise deviate from traditional syntheses.

Two pollutants in the beginning product, succinimide and a various acquired of the exactsame moiety are eliminated throughout a lateron book response. It was confessed this specific synthesis is slower, although the method is practical for producing several kgs of cGMP MDMA according to MAPS.

Purity at scale

The MDMA produced in the last phase was 99.26% pureness — a great grade for the cartel. But recrystallization in isopropanol alcohol produced a 99.96% pureness with an 85.5-82.6% yield, for a Heisenberg, cGMP grade MDMA-salt.

Residual solvents account for much of the left behind pollutants. 2-proponal was recognized as the most plentiful recurring by HPLC analysis — however less than 0.05% stayed. Some solvents and residuals have rigorous tolerance limitations and any pollutant above 0.1% is a cause for more metrology.

Two more pollutants were determined after following the cGMP procedure. One of these happens from overcharged bleach (chlorine) and another after a response with bromine. Both pollutants were found however listedbelow 0.3%.

Crystal structures and the future

Two brand-new crystal structures of MDMA-HCL were recognized. The 3rd is the least steady, converting spontaneously to the veryfirst currently understood structure. And the 2nd is reproducible, albeit the veryfirst crystal structure of the salt is the most steady of the 3. Now, a completely steady MDMA-salt will be allset if the FDA authorizes the compound and its advantages.

But will safe requirements for artificial substances, particularly for compounds bring a medical and psychedelic calibre, stay wholesome? Or will the pharmaceutical-minded FDA usage the opportunity to evenmore starve financial practicality in foreign nations?

Until that endsupbeing noticeable, though, pharmaceutical production of psychedelics and MDMA at least grants clients a sustainable alternative. And with Phase 3 trials inprogress, it’s at least apparent the American Drug War has stoppedworking.

Let us understand what you believe of pharmaceutical MDMA in the remarks? Will the procedure conserve a forest and offer a sustainable choice, or starve a prospective foreign market?


  1. Nair, J. B., Hakes, L., Yazar-Klosinski, B., & Paisner, K. (2021). Fully Validated, Multi-Kilogram cGMP Synthesis of MDMA. ACS omega7(1), 900–907.