Cannabis Syrups Offer Anti-Inflammatory Effects & Improved Stability

The anti-inflammatory residential or commercial properties of marijuana have actually been well developed. [1] However, very little is learnt about marijuana syrups as an alternative technique of providing cannabinoids orally. A group of scientists from the University of Benin, Nigeria, have actually clarified the effectiveness and stability of marijuana syrups. [2]

Methods Used

The marijuana syrup included 100 mg/mL of an unrefined marijuana extract, sucrose, aspartame, propylene glycol as a provider, and ethylenediaminetetraacetic acid (EDTA), and salt metabisulphite (SMBs) as stabilizers. These were made into strengths of 5.0 and 10.0 mg/mL in 50 mL.

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Stability was examined under conditions with faster temperature levels. Anti-inflammatory activity was assessed utilizing paw edema caused by egg albumin in an animal design. The Reitman and Frankel colorimetric technique was utilized to examine the biochemical assay.


The unrefined cannabis and syrup solutions triggered differing degrees of anti-inflammatory results (reducing paw edema) that was dose-dependent. The activity was, nevertheless, more noticable in the syrup formulas as compared to the unrefined extract. Remarkably, propylene glycol, utilized as a provider, considerably increased anti-inflammatory activity.

The scientists assumed that “[t] he enhanced anti-inflammatory activity of the syrups over the unrefined extract might be partially credited to the solubilizing power, increased polar path for optimum absorption and beneficial partitioning of the anti-inflammatory constituent( s) of the extract by propylene glycol.”

The stability of the syrups was figured out by comparing the preliminary concentration with the last concentration after deterioration has actually taken place due to demanding conditions. Salt metabisulphite and EDTA enhanced the stability of the syrups.

The destruction of marijuana produces thermodynamically unsteady substances that might be tough to separate. [3] This takes place following responses triggering decarboxylation and isomerization. While doing so, THC and other unsteady parts might be lost. Stabilizers might be utilized to extend the rack life of marijuana syrups: 20-160 days in salt metabisulphite-containing syrup and an extra 2204 days in EDTA-containing syrup.


This research study reveals that creating a marijuana extract as a syrup enhances the anti-inflammatory results, in part from the propylene glycol contributed to the syrup as a provider and likewise the marijuana extract itself due to THC and cannabinol (CBN). The deterioration that happens due to direct exposure to difficult conditions follows the first-order kinetic design. Stabilizers such as EDTA and SMBs improve the stability of labile elements, thus increasing the life span by around 99%. The addition of SMBs and EDTA aid to extended service life without triggering substantial biochemical or haematological modifications in the topics. [2]


1- Nagarkatti P, Pandey R, Rieder SA, Hegde VL, Nagarkatti M. Cannabinoids as unique anti-inflammatory drugs. Future Med Chem 2009; 1( 7 ): 1333-1349 [journal impact factor = 3.808; times cited = 272]

2- Obonga W, Nnadi C, Okafor S, Omeje E, Igbinnaduwa P, et al. Anti-inflammatory activity and sped up stability research studies of unrefined extract syrup of Cannabis sativa Tropical Journal of Pharmaceutical Research .2019;-LRB- ( 2):295-301[journal impact factor = 0.533; times cited = 0]

3- Barnett G, Chiang CW, Perez-Reyes M, Owens SM. Kinetic research study of cigarette smoking cannabis. J Pharmacokinet Biopharm 1982;-LRB- ( 5 ): 495-506 [journal impact factor = 2.751; times cited = 30]

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