Cannabis Syrups Offer Anti-Inflammatory Effects & Improved Stability

The anti-inflammatory residential or commercial properties of marijuana have actually been well developed. [1] However, very little is learnt about marijuana syrups as an alternative technique of providing cannabinoids orally. A group of scientists from the University of Benin, Nigeria, have actually clarified the effectiveness and stability of marijuana syrups. [2]

Methods Used

The marijuana syrup included 100 mg/mL of an unrefined marijuana extract, sucrose, aspartame, propylene glycol as a provider, and ethylenediaminetetraacetic acid (EDTA), and salt metabisulphite (SMBs) as stabilizers. These were made into strengths of 5.0 and 10.0 mg/mL in 50 mL.

syrup
Photo by Pixabay

RELATED: Is Cannabis Better For Sports Injuries Than Traditional Painkillers?

Stability was examined under conditions with faster temperature levels. Anti-inflammatory activity was assessed utilizing paw edema caused by egg albumin in an animal design. The Reitman and Frankel colorimetric technique was utilized to examine the biochemical assay.

Results

The unrefined cannabis and syrup solutions triggered differing degrees of anti-inflammatory results (reducing paw edema) that was dose-dependent. The activity was, nevertheless, more noticable in the syrup formulas as compared to the unrefined extract. Remarkably, propylene glycol, utilized as a provider, considerably increased anti-inflammatory activity.

The scientists assumed that “[t] he enhanced anti-inflammatory activity of the syrups over the unrefined extract might be partially credited to the solubilizing power, increased polar path for optimum absorption and beneficial partitioning of the anti-inflammatory constituent( s) of the extract by propylene glycol.”

The stability of the syrups was figured out by comparing the preliminary concentration with the last concentration after deterioration has actually taken place due to demanding conditions. Salt metabisulphite and EDTA enhanced the stability of the syrups.

The destruction of marijuana produces thermodynamically unsteady substances that might be tough to separate. [3] This takes place following responses triggering decarboxylation and isomerization. While doing so, THC and other unsteady parts might be lost. Stabilizers might be utilized to extend the rack life of marijuana syrups: 20-160 days in salt metabisulphite-containing syrup and an extra 2204 days in EDTA-containing syrup.

Conclusion

This research study reveals that creating a marijuana extract as a syrup enhances the anti-inflammatory results, in part from the propylene glycol contributed to the syrup as a provider and likewise the marijuana extract itself due to THC and cannabinol (CBN). The deterioration that happens due to direct exposure to difficult conditions follows the first-order kinetic design. Stabilizers such as EDTA and SMBs improve the stability of labile elements, thus increasing the life span by around 99%. The addition of SMBs and EDTA aid to extended service life without triggering substantial biochemical or haematological modifications in the topics. [2]

References

1- Nagarkatti P, Pandey R, Rieder SA, Hegde VL, Nagarkatti M. Cannabinoids as unique anti-inflammatory drugs. Future Med Chem 2009; 1( 7 ): 1333-1349 [journal impact factor = 3.808; times cited = 272]

2- Obonga W, Nnadi C, Okafor S, Omeje E, Igbinnaduwa P, et al. Anti-inflammatory activity and sped up stability research studies of unrefined extract syrup of Cannabis sativa Tropical Journal of Pharmaceutical Research .2019;-LRB- ( 2):295-301[journal impact factor = 0.533; times cited = 0]

3- Barnett G, Chiang CW, Perez-Reyes M, Owens SM. Kinetic research study of cigarette smoking cannabis. J Pharmacokinet Biopharm 1982;-LRB- ( 5 ): 495-506 [journal impact factor = 2.751; times cited = 30]

Expand all Collapse all
Is Delta 8 federally legal?

Delta-8 is legal federally, and most state laws don't specifically address it. Due to ambiguities in the 2018 farm bill, which legalized hemp and hemp products, delta-8 is currently not prohibited by federal law.

What are the benefits of Delta 8?

In the human body, Delta-8 binds to the CB1 and CB2 receptors. Because it binds to both receptors simultaneously, users experience a milder cerebral high. When compared to the effects of THC, users describe a more clear-headed, productive, energetic, and upbeat feeling.

Is Delta 8 or CBD better?

Difference Between Delta-8 THC and CBD Delta-8 THC may not be as prominent as Delta-9 THC, but it is still among the predominant cannabinoids with psychoactive properties. However, CBD is NOT a psychotropic cannabinoid. While CBD can have better results in the long run, Delta-8 THC can give you a quick fix.

Can you fly with Delta 8?

Is it Legal to Fly with Delta-8-THC? Often, yes! It is legal to fly with Delta-8 when you are flying to and from areas where Delta-8 is legal, as long as the airline you choose doesn't specifically prohibit Delta-8 products.

Does Delta 8 help with anxiety?

Contains less than 0.3% Delta 9 THC. Good for chronic pain and anxiety relief. It does not cause paranoia or increased Anxiety.

Is Delta 8 a controlled substance?

Delta-8 is considered a Schedule 1 Controlled Substance by the US Drug Enforcement Administration (DEA) because it is known to cause psychoactive impairment to the consumer.

What is the difference between Delta-8 and Delta 9?

Delta-9 THC is a property of cannabis discovered all the way back in 1964. The primary difference between Delta-8 THC and Delta-9 THC is that Delta-8 is just a bit less psychoactive than Delta-9. This means that products with Delta-8 THC have a more gradual, and therefore more satisfying, effect on the consumer.

Does Delta-8 become 11 hydroxy?

Although in an edible form, Delta-8 THC can metabolize into a natural chemical called 11 Hydroxy tetrahydrocannabinol. Since 11 Hydroxy THC can only be absorbed through the liver, the molecule's possible psychoactive effects can last up to 6 to 8 hours during digestion.

Does Delta 8 make you sleepy?

According to the NCI, Delta-8 uniquely binds twice with cannabinoid receptors in the nervous system that play a role in sleep by calming down processes like breath, heart rate, and mental activity.

Does Delta 8 Flower get u high?

Delta-8 THC is one of the hottest topics in cannabis right now. It's a minor cannabinoid that can get you high like traditional THC, but much less so. Delta-8 found in small amounts in the cannabis plant and is often converted from other compounds like CBD.

How does Delta 8 affect the body?

5 benefits delta 8 could offer you According to the National Cancer Institute, delta-8 THC can bind to the CB1 receptor throughout the body. These receptors are part of our endocannabinoid system, which helps our body regulate and maintain homeostasis.

Does Delta 8 contain CBD?

Delta-8 is yet another compound derived from Cannabis sativa or the hemp plant. As you likely know by now, this is the same natural origin that CBD, THC, CBG, CBN, and CBC come from, too. Though all of these compounds are related to some degree, delta-8 is closest to CBD and delta-9 (also often known plainly as THC).

Does Delta 8 cause euphoria?

Delta-8 may not produce intense euphoria, but it will take effect pretty quickly. Depending on your mode of intake, of course, the time of impact will vary. If you vape it, you will experience the effects within 1 to 6 minutes. If you use a tincture, you will get the first effects after half an hour.

Is Delta 8 legal in all 50 states?

The Short Answer: Yes. Hemp-derived Delta-8 THC products, containing less than 0.3% D-9 THC is legal in all 50 states of the USA. But what if the extract contains more than 0.3% Delta-9 THC?

Can Delta 8 help you lose weight?

A research study from 2004 concluded that delta-8 helps increase appetite while promoting weight loss. This effect is certainly very unique, and scientists will do even more research on this subject. These effects might be due to the potential benefits delta-8 has on metabolism.

Does Delta 8 give you munchies?

Yes, Delta 8 can make you feel hungry. Delta 8 is an appetite-stimulating analogue of tetrahydrocannabinol (or THC). Of course this depends on the amount you smoke (vapes) or consume (edibles), but Delta 8 has been reported to stimulate your appetite, in some cases, even more than Delta 9 (marijuana).

Does Delta 8 make you laugh?

Whatever makes you laugh, Delta-8 is a great way to start the fun. In fact, we've developed Delta-8 products because we love to see people laugh.

What does Delta 8 convert to eating?

Delta-8 THC actually converts into delta-11 THC when processed through the digestive tract. Since delta-9 THC also converts into delta-11 THC when eaten, there's no special benefit to eating delta-8 THC. In general, research suggests that delta-8 has about two-thirds of the potency of delta-9.

Does Delta 8 affect your liver?

In the present study, we have demonstrated that Δ8-THCV exerted protective effects against liver I/R reperfusion damage by attenuating tissue injury, oxidative stress and inflammatory response.

Does Delta 8 make good edibles?

Our Delta-8-THC Gummies — Best for Beginners They contain 10 mg of delta-8-THC per gummy, which is a great dose to start your journey into edibles with. It will give you a relaxing buzz, and you can easily increase the dosage as needed. Our delta 8 gummies are made from a broad-spectrum hemp extract.

You May Also Like

About the Author: Delta-8